Tian Zhang Lab @ UVA

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We develop and apply quantitative proteomics and chemical biology approaches to understand how proteome integrity is maintained, remodeled, and disrupted in stress, aging, and disease.

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Advanced Mass Spectrometry-based proteomics technology

Quantitative and high-throughput proteomic method development

Chemical Biology

Proteome-wide small-molecule engagement and ligandability

Bioinformatics

Reveal hidden patterns, transform raw data to knowledge

Stress Biology

Stress-driven proteome remodeling

Aging & Disease

Proteome integrity across aging and disease models